Drinking coffee can help reduce inflammation and improve heart health
A new study suggests that caffeine in a cup of coffee in the morning may not just keep you awake, but it may also help curb inflammation associated with heart disease risk factors.
the researchers found that an inflammatory response was produced in some older adults, but not in other older humans. When it is highly activated, people often have high blood pressure and severe atherosclerosis.
but in laboratory experiments, there is evidence that caffeine blocks the inflammatory process.
however, no one has said that a cup of coffee in the morning is a panacea against aging.
&emsp, &emsp, a researcher at the Stanford University School of medicine in David, Furman, said the findings may help explain why previous studies have linked higher caffeine intake to longer life expectancy.
according to Furman, the human body “ it is possible that there are hundreds of ways of ” promote chronic inflammation and a variety of diseases.
he said, “ we identified one of them.
Furman adds that substances other than caffeine may also affect the inflammatory process. He pointed out that a good example is Ω -3 fatty acids (nutrients often found in fatty fish in, it can reduce inflammation).
Gabrielle, an assistant professor at the American College of medicine in Albany, Fredman, who was not involved in the study, cautioned not to place too much emphasis on the caffeine finding.
Fredman; “ really important ” yes, this study points to the development of a number of molecular therapies for chronic inflammation of the new “ target ”.
scientists have long believed that persistent low levels of inflammation can lead to most age-related chronic diseases, including heart disease, arthritis, dementia, and many cancers.
Fredman notes that existing anti-inflammatory drugs have side effects, including immune system suppression, which are not suitable for use in older adults.
therefore, she says, scientists are trying to develop therapies that target specific targets in this chronic inflammatory process.
whether caffeine is one of these therapies remains unclear.
Fredman; “ this study suggests that moderate caffeine intake is sufficient to suppress some of the inflammation.
however, Fredman stresses that it's too early to say what it all means. She pointed out that “ they did not carry out a clinical trial of caffeine testing. More research is needed, to be exact.
this study involved more than 100 adults. Over the past 10 years, these participants were involved in the study by providing blood samples and their history.
Furman and her team compared blood samples from younger and older age groups to see which genes were more activated in older adults.
they focused on two gene clusters in which all the members of the two genes seemed to play a synergistic role. These two genes are involved in the production of a potent inflammatory protein, IL-1β.
the result shows that these elderly people were divided into two groups: one or two gene clusters in elderly group activation (i.e. high activation group); two gene clusters in elderly group low activation (i.e. low activation group).
12 adults in the high activation group had high blood pressure, while only about 1 of the 11 adults in the low activation group had high blood pressure. Adults in the high activation group were also more likely to develop atherosclerosis.
and most importantly, their blood test results showed that the older adults had higher IL-1&beta levels in the high activation group. They also have higher levels of nucleic acid metabolites.
therefore, caffeine play a role in the
those in the low activation group drank more caffeinated beverages. This allows researchers to conduct further research in the laboratory.
first, the researchers incubated the immune system cells with nucleic acid metabolites commonly found in the highly active group. They found that these metabolites increased the activity of one of the inflammatory gene clusters. This then led to these immune cells to produce more IL-1β.
when injected into mice, they trigger a wide range of inflammation and hypertension.
next, the researchers incubated the immune cells with nucleic acid metabolites and caffeine. They found that caffeine appears to block the metabolites that trigger inflammation.
according to Fredman, these results provide some targets for developing anti-inflammatory therapies.
Fredman said previous studies have confirmed that IL-1&beta is often associated with higher levels in patients with cardiovascular disease. Currently, a clinical trial is testing a IL-1&beta inhibitor in patients with heart disease.
Fredman says, from a broader perspectiveThe new study will help to solve a basic problem.
she says, “ it can help us understand why some people are more likely to be older than others. Why do some people had a stroke at the age of 60, while others had lived 100 years, never had a stroke?
it is still unclear why some people have higher levels of inflammatory gene clusters, while others do not.
however, Fredman said, this is likely to be partly genetic. In this study, she adds, there is evidence that older people are more likely than those with high activationThe elderly in the low activation group were 8 times more likely to have at least one close relative to the age of 90.